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Detailed methods are provided in Methods (see Supplementary Digital Content, ). The severity of AEs or laboratory abnormalities was evaluated according to the definition by the Common Terminology Criteria for Adverse Events, version 5.0 ( 9) ( number, University hospital Medical Information Network Identify Document: 000041384). Laboratory parameters were assessed by blood and urine tests at baseline and in the postintake period. Subjects reported any adverse events (AEs) during the study period. GSRS was measured at baseline, 4 weeks, and 8 weeks after starting intake. Stool consistency was recorded at each bowel movement and analyzed as the rate of each score in every week throughout the study period. Stool consistency by BSFS ( 7) and subjective complaints by the Gastrointestinal Symptom Rating Scale (GSRS) ( 8) were assessed for constipation improvement. The placebo is designed to match the flavor, color, and taste of prune juice (see Table 1, Supplementary Digital Content, ). Subjects were randomly assigned to the prune juice group or placebo group and consumed 54 g of each test food in a day for 8 weeks. The criterion for chronic constipation was defined according to Rome IV as fewer than 3 bowel movements per week and/or hard stool defined by the Bristol Stool Form Scale (BSFS) 1 or 2, for the past 3 months, with symptom onset at least 6 months earlier ( 6). This study included subjects aged 20–75 years who presented symptoms of treatment-naive chronic constipation. Written informed consent was obtained from all subjects before their enrollment into this study. This study was conducted in accordance with the Declaration of Helsinki with the approval of the institutional review boards of the Miura Clinic (approval number: R2001) and Tokyo Medical University (approval number: T2021-0243). Until the end of the month, gamers can claim this legendary. 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Boys and girls should both be represented when conducting the activities. As Save the Children works to reach the most marginalised children, it is important that when conducting activities, the organisation pays special attention to the children who are not the most vocal, and ensures that the activities are conducted in an inclusive and gender-sensitive way, promoting the participation of all children. It is thus important that education and child protection colleagues work together in designing and implementing this project. One of the key aspects of the project is to address the issues one has uncovered (for instance ensuring that documentation is follow-up by providing a response, either through referral or through direct support). This project links child protection and education across the interventions. Globally, we aim to link experiences from these countries to the global advocacy and policy work. Where the context allows, we work through partners to engage armed non-state actors (ANSAs) among others to not disrupt education. This is a way to implement the Safe Schools Declaration through a bottom-up approach by engaging local schools and communities. This includes using participatory tools and methods to engage children. Locally, the project aims to secure protective learning environments in conflict and post-conflict situations, raise awareness among communities, school management and children, and build local and national level engagement to protect education. In the project, we work with children, school management and local communities, and work to influence local, national and global policies. The project builds on the Schools as Zones of Peace-model that was successful in ensuring children’s access to education in Nepal during the civil war, and uses components from this while linking it to the Safe Schools Declaration. Schools as Zones of Peace is a Save the Children led project that aims to secure boys and girls’ protection at school, and avoid that education is disrupted because of armed conflict. Save the Children has developed a project that aims to link the global work done on protecting education from attack to what happens at school level in affected countries. After last year's claim that Modern Warfare 3 Remastered would not happen, there is now new information. Logically, the rumor that Modern Warfare 3 will also get a remaster has been going around for a while now. In 2020, Modern Warfare 2 Campaign Remastered followed, which was a bit of a disappointment because, as the name suggests, only the campaign was remastered, the multiplayer didn't get remastered. With Modern Warfare Remastered, we already got the first part of the series in 2016, complete with campaign and multiplayer in fancier graphics. 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There are a lot of bug fixes and quality-of-life improvements we've been making lately that we didn't want to sit on until we did all of the Port Forward content, so we're going to be getting those out the door as a separate update first. We're tweaking our plans a bit by sneaking in an interim update before the big Port Forward update. He's been helping us keep the pace with development as the new baby takes up a lot of our time. So some big news is we've expanded the team a while back with the addition of Rich, who's an incredible programmer and artist. We've got some exciting stuff planned for this year and we've been hard at work to get it all to you! If -ibck -ri switches are used together, WinRAR process sets the priority specified in -ri switch. 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